Study on The Performance of Nebulizer for Pressurized Intraperitoneal Aerosol Chemotherapy (PIPAC)

Objective The study aims to investigate the performance of an atomized drug feeder for pressurized intraperitoneal aerosol chemotherapy (PIPAC).

Methods Laser diffraction spectroscopy was used to measure the median particle size and spray angle.

Results The smaller droplet diameter of aerosol was achieved when using a nozzle diameter of 0.2 mm and a nozzle thickness of 0.07 mm. The nebulizer could not produce steady-state aerosol when the liquid flow rate was less than or equal to 0.3 mL/s. When the liquid flow rate is greater than or equal to 0.5 mL/s, as the working pressure increases, the median particle size gradually decreases and the spray angle gradually increases.When the pressure exceeded or equaled 200 psi,as the liquid flow rate increases, the spray angle gradually increases.At a flow rate of 0.7 mL/s and working pressure of 300 psi, the median droplet diameter of aerosol D₅₀ was 16 μm with a corresponding spray angle up to 89.2°.

Conclusion As a novel intraperitoneal drug delivery technology, PIPAC requires further research focusing on reducing droplet sizes , expanding drug distribution , as well as improving tissue penetration and concentration levels.