Application of CT Radiomics in Predicting Differentiation Level of Lung Adenocarcinoma

Objective To investigate the value of prediction of the differentiation level in lung adenocarinoma based on CT radiomics model.

Methods Data from 507 patients with postoperative pathological confirmed lung adenocarcinoma and clearly defined differentiation level of lung adenocarcinoma were retrospective analyzed. The enrolled cases were divided into poorly differentiation group and moderate-to-high differentiation group based on the grading criteria. CT image features were extracted, and seven machine learning algorithms were used to construct prediction models to obtain the AUC, accuracy, specificity and sensitivity.

Results The poorly differentiation group consisted of 175 cases, while the moderate-to-high-differentiation group had 332 cases. The XGBoost model demonstrated the best performance, the AUC, accuracy, specificity, and sensitivity of this model on the validation set were 0.878, 0.829, 0.667 and 0.727.

Conclusion CT radiomics model can effectively predict the differentiation level of poorly differentiation and moderate-to-high differentiation in lung adenocarcinoma.