Abstract: Objective To study the effective method of comprehensive evaluation and analysis of hospital valuable medical equipment performance. Methods The operation performance of 6 valuable equipment was evaluated by cost-benefit method, comprehensive index method and public evaluation method. Results Utilize equipment information management methods for data collection and evaluation, and construct an assessment data model based on evaluation indicators from three aspects: equipment operation status, profitability status, and scientific research contribution. Conclusion Through the performance analysis of different types of valuable medical equipment, a more real and comprehensive quantitative analysis is carried out, which plays a key role in the reasonable purchase, efficient operation and avoiding idling.