Abstract: Objective Digital therapy is important in treating motor system disease. The outcome of digital therapy in post-operative rehabilitation of knee anterior cruciate ligament (ACL) reconstruction is assessed. Methods 142 patients are treated with digital rehabilitation therapy after ACL reconstruction. Patients’ pain score, joint motion, lower limb function score, anxiety score are statistically analyzed. Patients’ satisfaction, device usage and adverse events are documented. Results At post-operative 1st day, 8th weeks, 12th weeks, pain score are 4, 2, 1, knee joint range of motion are 55°, 110°, 143°, lower limb function score are 18, 56, 76, anxiety score are 32.5, 26, 23.5 respectively. Patients’ satisfaction are 9.4. Mean duration of device usage is (177.6±38.0) minutes per week. Rehabilitation-related and device-related adverse event does not happen. Conclusion Digital therapy promotes post-operative rehabilitation after ACL reconstruction.