Abstract: Objective In order to record the whole life process information of medical equipment and improve the management efficiency, this study proposes an informatization scheme for the whole life cycle management of medical equipment. Methods Relying on cloud-native, based on the software architecture of front-end and back-end separation, a mode of sub-account and sub-authority management of medical equipment was designed to integrate maintenance work orders, operation reports and other functions, and manage medical equipment data in a structured and platform-based manner. Results Comparing the equipment failure rate, maintenance response time, and average inventory time per device before and after the system operation, the differences are statistically significant (P<0.05). Conclusion The system can realize the work collaboration of maintenance engineers, equipment users, and equipment management personnel, and can trace the information of the whole life cycle of the equipment.