正电子发射断层扫描-直线加速器在生物引导放疗中的应用

Application of PET-LINAC in Biology-guided Radiotherapy

摘要: 生物引导放疗（biology-guided radiotherapy，BgRT）是一种将PET-CT与直线加速器（LINAC）相结合的外照射放疗方式。BgRT通过PET示踪剂，利用从肿瘤组织处发射出的PET信号进行实时追踪，引导LINAC的治疗束对肿瘤靶区实现定位和照射。相比于传统的LINAC系统，BgRT系统的硬件设计、软件算法、系统整合和使用流程等诸多方面都更为复杂。RefleXion Medical公司研制出了全球首台BgRT系统，但该系统主推的BgRT核心功能尚处于研发阶段。该研究对BgRT的技术优势和潜在挑战等方面进行了探讨和展望。

Abstract: Biology-guided radiotherapy (BgRT) is a novel technique of external beam radiotherapy, combining positron emission tomography-computed tomography (PET-CT) with a linear accelerator (LINAC). The key innovation is to utilize PET signals from tracers in tumor tissues for real-time tracking and guiding beamlets. Compared with a traditional LINAC system, a BgRT system is more complex in hardware design, software algorithm, system integration and clinical workflow. RefleXion Medical has developed the world's first BgRT system. Nevertheless, its actively advertised function, PET-guided radiotherapy, is still in the research and development phase. In this review study, we presented a number of issues related to BgRT, including its technical advantages and potential challenges.