Abstract: Objective In order to solve the problems of equipment comprehensive management in grade A hospitals, such as complicated work, low maintenance efficiency, error-prone, non-standard management process, et al. A set of efficient information-based medical management equipment platform was designed to serve the concept of medical departments. Methods B/S (browser and server) architecture and WeChat official accounts technology were adopted to construct the application end and WeChat official accounts client developed by Web technology, and MySQL server was selected as the system database technology. Results Asset management, equipment maintenance, quality control management, equipment leasing, data statistical analysis and other modules were integrated into the system, which optimized and standardized the medical equipment management process, improved the work efficiency of equipment management personnel, and improved the opening rate of medical equipment. Conclusion Intelligent management by means of computer technology can effectively improve the utilization rate of hospital equipment, improve the level of hospital informatization and fine management, and contribute to the informatization development of medical engineering department.