快速心律失常脉冲电场不可逆电穿孔消融治疗研究进展

      Progress in the Treatment of Tachyarrhythmia by Pulsed Electric Field Ablation Catheter Ablation

      • 摘要: 脉冲电场(PEF)提供高能瞬时脉冲释放能量至心肌细胞膜,产生不可逆电穿孔,细胞内容物泄漏,破坏细胞内环境稳态,导致细胞死亡,炎症反应轻微。PEF作为非热消融能量来源,推动心律失常消融导管的设计及应用进入了新的阶段。目前已明确双相PEF为PEF消融最优波形。9极中空环形阵列电极IRE消融导管、篮状花瓣状IRE消融导管及可同步切换射频消融和PEF消融的Lattice-tip消融导管在房颤PEF消融临床研究用的安全性和有效性得到肯定,但仍需进一步探讨。国内快速心律失常PEF消融相关研究正在进行之中。该文就脉冲电场消融导管的设计和应用最新进展进行综述。

         

        Abstract: Pulsed electric field(PEF) provides high-energy instantaneous pulse and release energy to myocardial cell membrane, resulting in irreversible electroporation and causes myocardial cell contents leakage, destruction of intracellular homeostasis, cell death, and slight inflammatory response. PEF as non-thermal energy promotes the design and application of arrhythmia ablation catheter to enter a new stage. There are currently limited clinical studies that have proved the safety and effectieness of Farawave PEF catheter, PVAC GOLD PEF catheter, Lattice-tip Sphere-9 PEF and radiofrequency (RF) catheter used for atrial fibrillation ablation, but still need further discussion. The research of atrial fibrillation ablation with PEF is under study in China. In this paper, the design and application of PEF ablation for tachyarrhythmia are reviewed.

         

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