Abstract: Silk fibroin has the characteristics of good biocompatibility, mechanical properties, degradation performance and easy shaping, which makes silk fibroin become the focus of biomedical material preparation and research, and has received extensive attention. This article reviews the prior art methods of silk fibroin degumming, dissolution and regeneration processing. The specific applications of silk fibroin materials in the field of biomedical materials are reviewed, and the application prospects of silk fibroin in the field of biomedical materials are prospected.