基于双磁路磁珠法的血凝仪检测模块设计

      Design of Detection Module in Coagulometers Based on Dual-magnetic Circuit Beads Method

      • 摘要: 血凝仪(即血液凝固分析仪)是一个对凝血反应中一系列与血栓和止血密切相关的项目进行检测,从而为医疗诊断和治疗分析提供准确检测结果的产品。该团队在研究、总结了传统的血凝检测方法和原理的基础上,提出了一种基于双磁路磁珠法的血凝检测方法,并设计开发了使用此方法的血凝检测模块。在适当磁场强度条件下,通过检测血浆凝固时磁珠的运动变化来确定血浆的凝固时间。在调节出最适合的磁场强度之后,通过对血浆活化部分凝血活酶时间(APTT)进行测试,初步验证了血凝检测方法的有效性以及血凝检测模块的潜在价值。

         

        Abstract: Coagulometer, known as blood coagulation analyzer, is a product that can provide accurate test results for medical diagnosis and treatment analysis by detecting a series of items closely related to thrombosis and hemostasis in coagulation reaction. On the basis of previous traditional methods, and with our deep understanding about the principles of hemagglutination detection, we propose a hemagglutination detection method by using the dual-magnetic circuit beads method. Then, the corresponding hemagglutination detection module is designed. The coagulation time of plasma can be measured by detecting the movement of the magnetic beads when the magnetic field intensity is appropriate. The activated partial thromboplastin time(APTT) of plasma is tested when the most suitable magnetic field intensity is found. The results preliminarily show that this blood coagulation test method is valid and the corresponding test module has a potential value in business.

         

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