Abstract: In order to study the effects of sleep-disordered breathing on human physiology and function, and to accurately and objectively evaluate the level of human sleep quality at night, it can help patients with respiratory disorders improve sleep quality. This paper elaborates the development process of a new multi-parameter sleep quality evaluation system from the hardware circuit design, software and algorithm analysis design of the system. The system hardware platform collects the physiological signals of the 11-channel nighttime sleep period, and displays and stores them in real time on the monitoring platform. After collecting the sleep data of the whole night, it can effectively assist the sleep doctor to sleep by combining the judgment of the sleep-time respiratory disorder, the determination of the sleep cardiovascular event, the determination of the sleep-aware response event, and the sleep structure staging. The quality of sleep in patients with disorders was deeply evaluated.