Abstract: Objective To compare the performance of the GE cyclotron MINItrace system before and after the upgrade. Methods The upgrade of the MINItrace system included replacing the silver target with the Nb syetem and adopting the latest RF control and management system and lastest ion source system.The failrue rate and production efficiency were retrospectively analyzed before and after the upgrade. Results After the upgrade, the cyclotron failure rate decreased by 86.2%, the average capacity increased by 45%. Conclusion After the upgrade of MINItrace cyclotron, the failure rate is sharply reduced, and the production efficiency is grately improved.