Abstract: Objective To study the influence of disposable respiratory filter on the results of impulse oscillometery. Methods 90 healthy subjects were randomly selected and impulse oscillometery results were taken repeatedly through disposable respiratory filter and control device. All results were statistically analyzed. Results When using the disposable respiratory filter, respiratory impedance (Zrs) and resistance at all frequency (R5Hz-R35Hz) were significantly increased compared with the control device (P<0.01). The two measurements had a significant linear correlation (P<0.01) and a regression equation was established. The disposable respiratory filter did not exist in statistic difference to response frequency (Fres) and the elastic resistance (X5Hz-X15Hz) at all frequency(P>0.05). Conclusion The disposable respiratory filter can be used when testing pulmonary compliance, chest wall disease and obstruction outside the airway in impulse oscillometery system to avoid infection and ensure quality.