Abstract: Objective Aiming at the different characteristics of the various stages of medical equipment life cycle in hospital, research on the targeted and meticulous management mode. Methods Divides the whole life cycle of medical equipment in hospital into four phases, which are the selection demonstration period, purchase acceptance period, maintenance period, and retirement disposal period, and comparison with human fetal period, infant stage, adult stage and old age. Results With the meticulous management mode, the service quality of medical equipment in hospital has been improved, and the service benefits have been enhanced. Conclusion According to the respective characteristics of different stages, the corresponding meticulous management mode is implemented to make the management more scientific and standardized, and the operation is safer and more reliable, which escorts the whole life cycle of medical equipment in hospital.