Abstract: Objective To analyze the causes leading to hemodialysis machine & accessories faults and to give preventive measures.Methods The causes of 34 hemodialysis machine & accessories faults during hemodialysis process were studied through retrospective analysis from January 2017 to June 2018 in our hemodialysis center.Results The main factors were hemodialysis machine failure, water & electricity failure, dialytic pipeline failure, unstandardized using. The members in hemodialysis center benefited a lot from the faults, The engineers strengthened the preventive repair & quality control of hemodialysis machine, the monitoring of water & electricity. The nursing staff strengthened the quality control of the pipeline and the study of the principle & standard use of hemodialysis machine.Conclusion The study on hemodialysis machine & accessories faults improved the professional level of nurses & engineers, helped them to solve and prevent faults more precisely and improved the quality of hemodialysis.