Abstract: Objective To study the in vitro degradation of oxidized regenerated cellulose absorbable hemostatic products.Methods The morphology of the oxidized regenerated cellulose hemostatic products before and after degradation was observed by FTIR and SEM. The degradation products were determined by GPC and HILIC-ELSD.Results In the initial stage of degradation, there was a great change in morphology. GPC determined its degradation end point was 10 d; it was determined that its degradation products contained glucose (0.13%) and cellobiose (0.17%) and other components.Conclusion A method was established for determining the end point of degradation of oxidized regenerated cellulose, which provided a new idea and reference for the study of the degradation end point.