Abstract: Atrial fibrillation (AF) is one of the most common arrhythmia in clinic. Left atrial appendage closure is a new technique developed to block the left atrial appendage by minimally invasive intervention in patients with atrial fibrillation, it can help patients who are not applicable or tolerable to the long-term anticoagulation. This paper introduced the common classification of left atrial appendage, summarized and analyzed the limitation of existing left atrial appendage closure. Based on the perspective of clinical needs, it put forward the initial design idea of left atrial appendage closure and designed a new type of left atrial appendage closure. Corresponding animal experiment verified the safety and effectiveness of new left atrial appendage closure.