Abstract: Objective A remote wireless electrocardiogram (ECG) monitoring system is designed by using the CC2530 micro-controller as the device core. Methods Acquisition, conversion and data processing for ECG signals are realized on CC2530 micro-controllers. And the ECG data is transmitted to the coordinator by using ZigBee. It realizes the real-time monitoring of ECG signals and heart rate variability (HRV) data. Results The test results show that the maximum error of the designed ECG monitoring analyzer is 3 beats per minute and the average error is 1.6 beats per minute, which can meet the requirement of pharmaceutical industry standards of the People's Republic of China. Conclusion The ECG monitoring analyzer has good portability, high measurement precision and good practical application values.