Abstract: Objective To seek the ways of how to optimize medical equipment quality control, and improve the implementation effect of quality control for improving the quality of the medical equipment and clinical diagnosis and treatment. Methods Analysis the new problems of quality control, combined with quality control testing data, adverse events of medical equipments, and practical work of clinical diagnosis and treatment. Results Medical equipment quality control need to solve specific problems pertinently, and optimize from implementation of comprehensive quality control management system, establish standardized evaluation system and carry out research on new technologies of quality control, and so on. Conclusion To solve the new problems promptly and to optimize related work can effectively improve the effect of quality control.