Abstract: Objective To explore the changes and meaning of bilateral posterior cingulate cortex, hippocampus, precuneus, posterior cerebellum lobe to all the other parts of the whole brain for T2DM and T2DR patients.Methods The differences of functional connectivity strengthen expressed were calculated and analyzed between seed points to all the other parts of the whole brain after rs-fMRI scan by two sample t-test. Also The correlations of the functional connectivity with clinical parameters were discussed.Results The functional connectivity had changed between some seed points and other brain regions comparing T2DM to controls and T2DR to T2DM. The changed functional connectivity were also correlated with clinical parameters.Conclusion The changed brain regions of T2DM and T2DR were relevant to emotion, memory, cognitive and visual control.