Abstract: Objective In order to overcome the disadvantages of the common single handle cold scalpel such as cicatrix cutting inefficient, large amount of skin losses, margin concave and convex, cutting marks poor healing, a safe and general type of convenient installation and instantly removable "A" shaped scalpel handle was developed. Methods For the convenience of the single hand independent, cicatrix cutting smoothly and conveniently, man-machine design "A" shaped scalpel handle and application. Results The "A" shaped scalpel handle has good precision and controllability. When loading or unloading the blades, it's convenient, efficient and safe, free choice of direction. Conclusion The "A" shaped scalpel handle with cicatrix cutting single hand is independent, universal for all blades, can conveniently install and instantly remove, is portable and easy to storage, has wide range of applications. The prevention of sharp instrument injuries reduces the occupation injury risks and improves operation efficiency.