Abstract: Objective To observe the effect of modified method of contrast examination of upper gastrointestinal tract, and explore the application value. Methods 100 patients were examined with modified upper gastrointestinal barium radiography. Then compare it with conventional contrast. Results The excellent rate of improved upper gastrointestinal barium radiography was 87%,while the excellent rate of conventional contrast was 66%.The differences was statistically significant. Compared with the control group, improved upper gastrointestinal barium radiography provides high-resolution and high-contrast images. Conclusion The improved upper gastrointestinal barium double contrast radiography is provided with simple operation, and the structure of gastrointestinal tissue is clearly shown improving the definitive diagnosis rate of diseases.