Abstract: With retrospective case study, this paper classified, summerized and evaluated 47 reports induced by ozonic therapeutic instrument. The results showed:25 cases of adverse events were clearly related to the use of instruments; the cases mainly reported by equipment use enterprises; the delay treatment by instrument failure was the most common adverse event performances; adverse events might be relevant to the risk factors of product quality, technical operation, patient specificity and instrument disinfection. Monitoring should be strengthened in order to reduce the ozonic therapeutic instrument adverse events and maintenance of public safety.