高分辨率显微内镜成像系统的构建与初步应用

Construction and Preliminary Application of High Resolution Microendoscopy Imaging System

摘要: 高分辨率显微内镜（HRME）是基于高分辨率光纤和分子成像技术研发的一种新的成像方法，能够对组织进行实时成像。该文通过对HRME系统中激发光传导部、荧光图像传像部、光纤快速交换部和图像采集部等组成元件和光路的设计与优化，构建了一套HRME成像系统。利用HRME系统对动物胃肠道黏膜进行成像观察，结果表明HRME实现组织虚拟病理学成像具备可行性，为进一步临床研究奠定了基础。HRME作为一种即时组织病理学成像方法，有望成为组织即时诊断的一种新模式。

Abstract: High Resolution Microendoscopy (HRME) is a new imaging method which based on high resolution fiber and molecular imaging technology and it is possible to organize real-time imaging. After design and optimization of excitation light conduction part, fluorescent image transfer unit, optical fast switching unit and image capture unit, we constructe a HRME imaging system. We make an imaging observation of animal gastrointestinal tract by using HRME system and the results show that the feasibility of virtual pathology of HRME which lay the foundation for further clinical research. As an instant histopathological imaging method, HRME is expected to become a new immediate diagnosis model.