Abstract: The three-dimensional facial wrinkle measurement and quantification have important applications in many fields, which are implemented by an entire system proposed in this paper. The system uses stereo vision method based on structured-light to achieve three-dimensional facial wrinkle measuring, where the system calibration, corresponding points matching and three-dimensional reverse method are implemented. Furthermore, the facial wrinkle is considered as the noise attached on smooth facial profile so that the facial wrinkle is acquired quantitatively by three-dimensional noise acquisition and morphologic processing method. The experimental results show that this system can accomplish accurate facial wrinkle acquisition and objective quantification. This system has comprehensive applications as it is non-contact and it has high precision.