3D打印磷酸钙骨修复支架的研究进展

      Research Progress on 3D Printed Calcium Phosphate-based Bone Repair Scaffolds

      • 摘要: 磷酸钙因其化学组成与天然骨矿物相高度相似,兼具优异的生物相容性和良好的骨传导能力,已被广泛视为骨缺损修复领域的核心生物材料。近年来,随着3D打印技术的迅速发展,磷酸钙骨修复支架的制造水平实现了显著跨越,提升了其在复杂临床场景中的适用性。本文系统综述了制备3D打印磷酸钙骨修复支架的3D打印技术、结构和组成的改性策略及其当前面临的挑战和未来发展方向,以期为该类产品设计优化、临床转化和应用提供理论支持。

         

        Abstract: Calcium phosphate, due to its high chemical similarity to the mineral phase of natural bone, combined with excellent biocompatibility and favorable osteoconductive properties, has been widely recognized as a core biomaterial in the field of bone defect repair. In recent years, with the rapid advancement of 3D printing technology, the manufacturing level of calcium phosphate bone repair scaffolds has significantly improved, enhancing their applicability in complex clinical scenarios. This article systematically reviews the 3D printing technologies used in the preparation of calcium phosphate bone repair scaffolds, modification strategies for their structure and composition, as well as current challenges and future development directions, aiming to provide theoretical support for the design optimization, clinical translation, and application of such products.

         

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