Abstract: Diabetic wound healing is recognized as a severe clinical challenge. Its high incidence rate and high recurrence rate impose a heavy burden on both patients and society. Traditional treatment methods are considered to have limited effectiveness in precisely regulating the wound microenvironment and promoting complex tissue regeneration. For this purpose, recent research progress on 3D-printed scaffolds loaded with bioactive components in this field is reviewed. Various technical features of scaffolds are systematically analyzed. These include scaffolds loaded with synthetic drugs, natural extracts, nanomaterials, autologous fat, and cellular active components. Their effects on accelerating healing through pathways such as antibacterial, anti-inflammatory, and pro-angiogenic actions are evaluated. The study finds that 3D printing technology can precisely construct three-dimensional structures that match the wound. It also enables the controlled release of therapeutic factors. This provides a highly personalized therapeutic solution for diabetic wound repair. Although challenges remain regarding bioink performance, release precision, and clinical translation, this technology demonstrates significant potential for advancing wound repair towards precision and functionality.