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      3.0T大脑磁共振单体素点分辨波谱快速成像的可行性研究

      Evaluating the Brain Applicability of Rapid Single Voxel Point Resolved Spectroscopy in 3.0T Brain MRI

        摘要
      • 摘要:
        目的 探讨3.0T大脑磁共振单体素点分辨波谱（PRESS SV）快速成像序列在不同参数条件下的可行性，并与常规PRESS序列进行对比。
        方法 前瞻性选取温州医科大学中西医结合医院2022年9月至2024年8月期间的200例脑部磁共振扫描患者，其中男性114例，女性86例，平均年龄（47.12±11.47）岁。基于实测线宽、扫描总数、回波时间（TE）3种参数组合，将患者分为5组：①对照组：小线宽常规短TE组（39例）；②观察组：大线宽快速短TE组（39例）、大线宽快速长TE组（38例）、小线宽快速短TE组（40例）、小线宽快速长TE组（44例）。为验证参数变量影响，对照组行两次常规PRESS SV序列扫描；观察组行快速PRESS SV扫描后追加常规PRESS SV作为对照。分析各组内两次扫描所得代谢物SNR值及半定量值的差异；并对影响图像判读的参数进行Logistic回归分析。
        结果 ①5组两次扫描的代谢物半定量值差异均无统计学意义（P＞0.05）。②快速PRESS SV序列的Cr SNR均值约为常规序列的（57.11±4.07）%，差异有统计学意义（P＜0.05）。③大线宽快速PRESS SV序列在体素为4.5 cm3时，图像质量较差，无法判读率是常规序列的1.5~2倍。④Logistic回归分析显示，当体素从8 cm3减小至4.5 cm3时，图像不可判读的风险增加3.45倍；线宽≥9 Hz时风险增加2.09倍；TE=144 ms时风险增加2.08倍。
        结论  3.0T大脑快速PRESS SV序列可以替代常规PRESS SV序列应用于临床扫描，缩短扫描时间；当线宽≥9Hz时，建议扫描8 cm3体素或35 ms回波时间，以提高成像成功率。

         

        Abstract:
        Objective To explore the feasibility of the 3.0T brain magnetic resonance single-voxel point-resolved spectroscopy (PRESS SV) fast imaging sequence under different parameter conditions and to compare it with the conventional PRESS sequence.
        Methods Prospectively, 200 patients who underwent brain MR scans at the Integrated Traditional Chinese and Western Medicine Hospital of Wenzhou Medical University from September 2022 to August 2024 were selected, including 114 males and 86 females, with an average age of (47.12 ± 11.47) years. Based on three parameter combinations—measured linewidth, total number of scans, and echo time (TE)—the patients were retrospectively divided into 5 groups: ① Control group: small linewidth conventional short TE group (39 cases); ② Observation groups: large linewidth fast short TE group (39 cases), large linewidth fast long TE group (38 cases), small linewidth fast short TE group (40 cases), small linewidth fast long TE group (44 cases). To verify the influence of parameter variables, the control group underwent two conventional PRESS SV sequence scans; the observation groups underwent fast PRESS SV scans followed by an additional conventional PRESS SV scan as a control. The differences in metabolite SNR values and semi-quantitative values obtained from the two scans in each group were analyzed; Logistic regression analysis was performed on the parameters affecting image interpretation.
        Results ① The differences in metabolite semi-quantitative values between the two scans in all 5 groups were not statistically significant (P＞0.05). ② The mean Cr SNR of the fast PRESS SV sequence was approximately (57.11±4.07)% of that of the conventional sequence, and the difference was statistically significant (P＜0.05). ③ For the large linewidth fast PRESS SV sequence with a voxel size of 4.5 cm3, the image quality was poor, and the rate of uninterpretable images was 1.5−2 times that of the conventional sequence. ④ Logistic regression analysis showed that when the voxel size decreased from 8 cm3 to 4.5 cm3, the risk of uninterpretable images increased by 3.45 times; when the linewidth was ≥9 Hz, the risk increased by 2.09 times; and when TE=144 ms, the risk increased by 2.08 times.
        Conclusion The 3.0T brain fast PRESS SV sequence can replace the conventional PRESS SV sequence for clinical scanning, shortening the scan time; when the linewidth is ≥9 Hz, it is recommended to use a voxel size of 8 cm3 or a TE of 35 ms to improve the success rate of imaging.

         

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