Abstract: This study evaluated the healing-promoting effect and applicability of seven new dressings in chronic wound. A chronic wound model was established using 48 db/db diabetic mice, which were randomly divided into 8 groups (control, polymer film, alginate, foam, hydrocolloid, hydrogel, carbon fiber, and silver dressing groups). Regular monitoring was conducted on the 5, 10, 15, and 20 days after surgery, and a comprehensive evaluation was performed based on healing rate, histopathology, and semi-quantitative scoring. The results showed that, except for the polymer film dressing group, the healing-promoting effect of all other dressing groups was significantly better than those of the control group (P＜0.05), with the hydrocolloid, carbon fiber, and silver dressing groups demonstrated particularly outstanding efficacy. This study systematically compared the efficacy differences of seven dressings, and combined them with the adhesion, exudate volume and infection risk to provide a basis for clinical dressing selection.