Abstract: 3D printing technology, employing a layer-by-layer construction method, enables the fabrication of intricately shaped and customizable bolus. In contrast to traditional preparation methods, 3D printing technology addresses challenges such as poor bolus fit and cumbersome production processes, offering a novel approach to efficient and personalized bolus fabrication. This article discusses the research progress of 3D printing technology in radiotherapy tissue compensators from aspects such as the preparation process, clinical application, and research advancements, combined with the actual printing experience of our department of radiation oncology.