改良水脂分离技术定量T2*值及FF值对颈椎间盘退变的应用研究

      Application Research of mDIXON-Quant Quantitative T2* Values and FF Values in Cervical Intervertebral Disc Degeneration

      • 摘要:
        目的 探讨磁共振成像改良后的水脂分离(mDIXON-Quant)技术定量T2*值及脂肪分数(FF)值在颈椎间盘退变程度中的临床价值。
        方法 收集阜阳市人民医院2019年3月至2024年1月行常规颈椎MRI及mDIXON-Quant检查的患者118例,测得其C2/3~C6/7椎间盘的T2*值及上、下位椎体FF值,根据普菲尔曼(Pfirrmann)标准对颈椎间盘进行退变程度分级,对不同患者的T2*值及FF值与Pfirrmann分级进行对比,用Spearman相关性分析T2*值、FF值与Pfirrmann分级的相关性。
        结果 在颈椎间盘层面内Ⅰ级、Ⅱ级、Ⅲ级、Ⅳ级、Ⅴ级T2*值全部呈递减趋势(P<0.05)。FF值在上位颈椎椎体的递减顺序为Ⅳ级、Ⅴ级、Ⅲ级、Ⅱ级、Ⅰ级(F=93.28,P<0.05),在下位椎体的递减顺序为Ⅳ级、Ⅲ级、Ⅴ级、Ⅱ级、Ⅰ级(F=112.037,P<0.05)。Spearman相关性分析表明,颈椎间盘T2*值与Pfirrmann分级呈负相关(P<0.05),上、下位椎体FF值与Pfirrmann分级呈正相关(P<0.05)。
        结论 mDIXON-Quant技术定量T2*值及FF值能够应用于颈椎间盘退变,对临床精确诊断、评估治疗效果等具有重要价值。

         

        Abstract:
        Objective To investigate the clinical value of MRI modified water-lipid separation technique (mDIXON-Quant) in terms of T2* values and fat fraction (FF) values for evaluating the degree of cervical intervertebral disc degeneration.
        Methods A total of 118 patients who underwent routine MRI of the cervical vertebra and the mDIXON-Quant examination in Fuyang People's Hospital from March 2019 to January 2024 were collected. The T2* values of C2/3 to C6/7 intervertebral discs and FF values of the upper and lower vertebral bodies were measured. Cervical intervertebral disc degeneration was graded according to the Pfirrmann criteria. The T2* values and FF values of different patients were compared with the Pfirrmann grades, and the correlation between T2* values, FF values, and Pfirrmann grades was analyzed by Spearman correlation.
        Results The T2* values of cervical intervertebral discs in grades I, II, III, IV, and V all showed a decreasing trend (P<0.05). The decreasing order of FF values in the upper cervical vertebra was IV, V, III, II, and I (F=93.28, P<0.05), and the decreasing order of FF values in the lower cervical vertebra was IV, III, V, II, and I (F=112.037, P<0.05). Spearman correlation analysis showed that the T2* values of cervical intervertebral discs were negatively correlated with the Pfirrmann grades (P<0.05), and the FF values of the upper and lower vertebrae were positively correlated with the Pfirrmann grades (P<0.05).
        Conclusion The mDIXON-Quant technique can be used to quantify the T2* values and FF values of cervical intervertebral disc degeneration and plays an important role in accurate clinical diagnosis and evaluation of treatment effects.

         

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