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      基于SCT的健康颈髓形态学参数定量研究

      Study of Healthy Cervical Spinal Cord Morphometrics Using SCT

        摘要
      • 摘要:
        目的 使用脊髓分析平台测定健康颈髓的形态学参数并研究性别，年龄和颈髓节段对这些参数的影响。
        方法 采用回顾性研究方法，采集184名健康被试的颈髓磁共振图像并计算形态学参数，研究性别、年龄和节段对横截面和离心率的影响，对不同节段的横截面，前后径及左右径进行相关性分析。
        结果 男性的颈髓横截面在C2−C7节段均显著大于女性（P＜0.05）。在C2−C6节段，青年组与中年组横截面差别无统计学意义且均显著大于老年组。C4节段的横截面最大，C7节段的横截面最小，C4和C5节段的离心率显著大于其他节段（P＜0.05）。在C2−C7节段，横截面与前后径，左右径均存在线性关系。
        结论 该研究对今后通过归一化方法减少个体间差异，利用上述形态学参数作为生物标志物研究颈髓病变具有重要意义。

         

        Abstract:
        Objective  To utilize Spinal Cord Toolbox (SCT) to measure the morphometric measures of healthy cervical spinal cords and explore the impact of gender, age and vertebral levels on them.
        Methods  As a retrospective study, magnetic resonance images of one hundred and eighty-four healthy adults were included and postprocessed. Then, cross-sectional area (CSA), eccentricity, anteroposterior diameter (AP) and right-left diameter (RL) were each computed for every subject. Then, impact of gender, age and vertebral level on CSA and eccentricity were explored. Moreover, linear correlation analysis was conducted among CSA, AP and RL.
        Results  Male CSA is significantly larger than female CSA (P<0.05). For C2−C6, CSAs of younger and middle-aged group are both significantly larger than that of older group. CSA of C4 is the largest whereas CSA of C7 is the smallest. Eccentricity values of C4 and C5 are significantly larger than that of other vertebral levels. Linear correlation is established between CSA, AP and RL.
        Conclusion The results allow for minimizing inter-subject variability using normalization, and thereby highlighting the importance of morphometrics as biomarkers in the research of cervical spinal lesion.

         

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