中央型肺癌容积旋转调强放疗计划中减少肺低剂量体积的研究

张皓嘉; 张毅; 金海洁; 游士虎; 甘家应; 胡银祥

doi:10.12455/j.issn.1671-7104.240237

中央型肺癌容积旋转调强放疗计划中减少肺低剂量体积的研究

Method of Reducing Low-Dose Lung Volume in VMAT on Central Lung Cancer Planning

摘要

摘要:
目的研究中央型肺癌容积旋转调强放疗计划设计中，采用不同弧段以及不同形状剂量限制区，探讨有效降低肺V₅、V₁₀和肺平均剂量（mean lung dose, MLD）的方法。
方法对入组病例分别设计5组计划：A组为全弧射野，B组为部分弧射野，C、D、E组为全弧射野，分别增加竖长条状、半环状和三角状剂量限制区，比较各组靶区的剂量学相似性及全肺V₅、V₁₀、V₂₀和MLD的剂量学差异。
结果 B、C、D、E组与A组相比，靶区均匀性指数和适形度指数均降低，全肺V₅和V₁₀明显降低。C、D、E组与A组相比，MLD降低。
结论采用全弧射野同时增加剂量限制区，可有效降低肺V₅、V₁₀和MLD。

Abstract:
Objective To study effective methods for reducing lung V₅, V₁₀, and mean lung dose (MLD) in the design of volumetric modulated arc therapy for central lung cancer by using different arc configurations and dose-limiting blocks designs.
Methods Five groups of plans were designed for the enrolled patients. Group A used a full-arc field. Group B used a partial-arc field. Groups C, D, and E used full-arc fields with vertical-length, semi-ring, and triangular dose-limiting blocks added respectively. The dosimetric similarities of target areas and the dosimetric differences in lung V₅, V₁₀, V₂₀, and MLD among the groups were compared.
Results Compared with group A, groups B, C, D, and E had decreased homogeneity and conformity of the target area, but significantly lower V₅ and V₁₀ of the whole lung. The MLD of groups C, D, and E was lower than that of group A.
Conclusion Using a full-arc field combined with dose-limiting blocks can effectively reduce lung V₅, V₁₀, MLD, and monitor units (MU).

HTML全文

参考文献(21)

施引文献

资源附件(0)