Abstract: Needle-free jet injectors refer to a kind of medical device that uses a specific device to form a small, high-speed jet of medication to pierce the human skin, thereby achieving the delivery of medication into the human body without the use of needles. In the past few decades, needle-free jet injectors have undergone many changes with the development of healthcare systems and advancements in related technologies. In this article, the history, research status, and clinical application of needle-free jet injectors are introduced. The principles of different driving modes for needle-free jet injectors are briefly summarized, and their respective advantages and the existing problems are summarized. Combining the current research status and market application, the technical problems faced by the development of needle-free jet injectors are analyzed. Under the background of intelligent and automatic development of medical equipment, the future development and opportunities for needle-free jet injectors are prospected.