鼻咽癌混合自动计划方案的临床实用性评估

      Evaluation of Clinical Practicability of a Hybrid Automated Treatment Planning for Nasopharyngeal Carcinoma

      • 摘要:
        目的 自动计划是目前常用替代人工计划的方案。该研究通过比较自动计划与手动计划的结果,评估商用治疗计划系统的自动计划算法在鼻咽癌治疗方面的临床表现。
        方法 该研究共纳入14名鼻咽癌患者,每位患者采用3套不同的临床目标分别生成3个基于3D剂量预测的自动计划和3个基于脚本的自动计划,与临床使用的手动计划相比较。
        结果 基于3D剂量预测的混合自动计划在PTV剂量覆盖上的表现与手动计划相当,在绝大多数危及器官保护上能达到手动计划水准,而基于脚本的自动计划在部分危及器官,尤其腮腺上表现不佳。
        结论 基于3D剂量预测的混合自动计划能够达到手动计划的水准,并且随临床目标的改变也有着较好的稳定性。

         

        Abstract:
        Objective Automatic planning is a commonly used alternative to manual planning. The study evaluated the clinical performance of automated plans available in commercially available treatment planning systems for NPC treatment by comparing hybrid automated plans with manual plans.
        Methods A total of 14 patients with nasopharyngeal carcinoma were enrolled in the study. Each patient used 3 different sets of clinical goals to generate 3 automatic plans based on 3D dose prediction and 3 automatic plans based on dose drop prediction, respectively, compared with the manual plan used in clinic.
        Results The performance of the automatic plan on PTV was comparable to that of the manual plan. Automatic planning based on 3D dose prediction can achieve the level of manual planning in most organs at risk, but automatic planning based on dose drop prediction can not perform well in some organs at risk, especially the parotid gland.
        Conclusion The hybrid automatic schedule based on 3D dose prediction can reach the level of manual schedule, and has good robustness with the change of clinical objective.

         

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